Product Code

:  SSPC-A00382

CAS No.

:  783292-37-5

Chemical Name

:  Trans-Abacavir

Synonyms

:   [(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol (as per EP); 9-[(1R ,4S )-4-(tert-Butoxymethyl)cyclopent-2-enyl]- N 6 -cyclopropyl-9H -purine-2,6-diamine (as per USP);

Molecular Formula

:   C₁₄H₁₈N₆O

Molecular Weight

:  286.34

Appearance

:  NA

Storage

:  2-8°C Refrigerator

Application

:  Trans-Abacavir (Abacavir EP Impurity D) is an impurity of Abacavir). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.